Do they Intersect with each other?

I’m testing this 3 Main Targeting Setting:

1 - Keywords Targeting
2 - Direct Channels (In Placements) Targeting
3 - Topics Targeting

My question is:

Do this 3 main targeting setting intersect with each other?
Do they interfere between them, or do they not?
Is this like facebook ads audience crossings?

If they are, it can be interesting to do something really cunning there.

and, anyway, I think it is smarter to just build new adgroups for each different targeting setting, and test it like a scientist all under the same Control AD, the Control Lander, and the same Control Offer.

But I would like to know because maybe I’m totally wrong.

Cheers!